Miocardial Infarction Genetic Factors for Heart Attack.
We often develop an interest in fitness and exercise because
we have seen the effect of an unhealthy lifestyle on other
people's health. Where the people we observe are relatives,
there is an added interest as the health risks experienced
by an individual may be influenced by their genetic heritage.
There is the possibility that a person can inherit their
body shape from their parents. Factors such as
- BMI (Body
Mass Index) over 30
- gender (males generally have a higher
- the presence of greater amounts of visceral fat
(fat interspersed throughout the inner abdominal organs)
can all play a part in our predisposition to Miocardial Infarction
or heart attack.
Genetic and Social Factors in the Occurrence of Miocardial Infarction
The parents of an MI patient need to be examined also, as one or
both parents could have had either diagnosed or undiagnosed type
2 Diabetes. The patient’s underlying cholesterol level would
be a product of his genetic history.
McPherson et al (2007), showed that a sequence of DNA on chromosome
9 can be attributed to MIs in 20% of people of European origin.
Its presence highlights people at risk of early heart attack.
Genetic factors have also been shown to influence thrombotic and
bleeding outcomes following treatment for MI, and can be a major
contributor to complications associated with treatment (Shields
et al. 2002).
Socio-cultural background and career choice could be an important
factor in determining someone’s health and risk of having
a miocardial infarction, MI or heart attack. Men from predominantly
working-class backgrounds are more likely to have poor dietary patterns
due to lack of money to purchase better quality foods, or lack of
education on what is healthy and what foods should be consumed in
moderation. So called ‘office’ jobs present with a inherent
risk of their own. The sedentary lifestyle associated with these
jobs could lead to a greater likelihood of weight gain from the
lack of exercise and the possible poor faculties in the workplace
leading to a reliance on convenience foods.
McPherson R, Pertsemlidis A, Kavaslar N, et al. A common allele
on chromosome 9 associated with coronary heart disease.
Science 2007; DOI:10.1126/science.1142447.
D C Shields, A P Fitzgerald, P A O'Neill, C Muckian, D Kenny, B
Moran, C P Cannon, C E Byrne and D J Fitzgerald
The Pharmacogenomics Journal (2002) 2, 182?190